Resetting of the baroreceptor in hypotension in rats.
نویسندگان
چکیده
1. A progressive but incomplete adaptation of the aortic baroreceptor was observed after 1 and 6 h of hypotension in rats subjected to controlled bleeding. Administration of phenoxybenzamine produced a greater downward displacement of baroreceptor activation range. 2. Complete adaptation was observed after 48 h of maintained hypotension in rats treated with reserpine. 3. The range of the aortic baroreceptor activation shifted upward as pressure returned to normotension, indicating the reversibility of baroreceptor adaptation in hypotension.
منابع مشابه
Antihypertensive Drugs Distinctly Modulate the Rapid Resetting of the Baroreceptors
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We investigated the distinct ability of various antihypertensive drugs to modulate the extent (%) of rapid (15 minutes) resetting of the baroreceptors of normotensive rats to hypotensive levels. In one protocol, hemorrhage produced a complete resetting to hypotension in rats chronically treated (6 days) with captopril. Also, hemorrhage produced only partial resetting in rats acutely treated (10...
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عنوان ژورنال:
- Clinical science and molecular medicine. Supplement
دوره 3 شماره
صفحات -
تاریخ انتشار 1976